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Dextran Sulfate Sodium Salt(DSS) 结肠炎建模用葡聚糖硫酸钠盐 MW:36000~50000
产品货号:60316ES25
产品规格:25 g
产品价格:¥ 1255
类别:生化试剂

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  • 产品信息

    产品名称

    产品编号

    规格

    目录价(元)

    Dextran Sulfate Sodium Salt(DSS)

    结肠炎建模用葡聚糖硫酸钠盐 MW:36000~50000  

    60316ES25

    25 g

    1255

    60316ES60

    100 g

    3855

    60316ES76

    500 g

    16855

    60316ES80

    1 kg

    32855


    产品描述


    硫酸葡聚糖钠盐(Dextran sulfate,DSS)是葡聚糖的聚阴离子衍生物,由葡聚糖和氯磺酸的酯化反应形成。其中含硫量约为17%,相当于葡聚糖分子的每个葡萄糖残糖中平均含1.9个硫酸基团。DSS具有几个特点:1)聚阴离子复合物,可溶于水,形成无色水溶液;2)纯度高,且具有良好的稳定性;3)可被自然降解。

    炎症性肠炎(IBD)是一种慢性、易复发的胃肠道感染,会提升肠道肿瘤发生的危险性,主要包括UC和克罗恩病(Crohn disease, CD)。自1985年首次报道采用葡聚糖硫酸钠(dextran sulphate sodium, DSS)制备出仓鼠溃疡性结肠炎模型以来,已有大量研究证明DSS结肠炎模型与人类溃疡性结肠炎相似。DSS结肠炎模型的组织学特点、临床表现、发病部位和细胞因子增殖情况都与人类溃疡性结肠炎(ulcerative colitis, UC)极为相似。该模型的造模条件和操作方法简单,造价便宜,重复性好,便于掌握和推广;可根据实验目的调整DSS浓度和给药时间,建立急性、慢性和急慢性交替性模型。


    产品性质

    中文别名(Chinese Synonym)

    硫酸葡聚糖;葡聚糖硫酸氢钠,糖酐酯,硫酸葡聚糖钠盐

    英文别名(English Synonym)

    Dextran Sulfate Sodium Salt, DSS; Dextran Sodium Sulfate

    CAS 号(CAS NO.)

    9011-18-1

    分子式(Molecular Formular)

    (C6H7Na3O14S3)n

    外观(Appearance)

    白色或灰白色粉末

    溶解性(Solubility)

    易溶于水,微溶于乙醇。

    结构(Structure)

    blob.png


    溶解方法

    溶于水(100 mg/ml澄清或者轻微模糊的黄色溶液)。具体使用浓度需根据造模类型,参考相关文献或通过预实验摸索确定。


    运输与保存方法

    室温运输与保存,有效期2年。


    注意事项

    1)为了您的安全和健康,请穿实验服并戴一次性手套操作。
    2)本产品仅作科研用途!

     

    数据展示

     

    客户1:

    客户来源:中国医学科学院北京协和医学院放射医学研究所(天津)

    小鼠类型:6~8周雄性C57BL/6J小鼠

    造模方法:1.5% (w/v) DSS自由饮用15天

    图片1.png 

    1Yeasen DSS(Cat#60316ES)小鼠造模实验结果(Yuan Li, et al. Gut Microbes2019789-806. IF=10.245

    客户2:

    客户来源:南京农业大学

    小鼠类型:体重为 20~22 g的8周龄雄性C57BL/6小鼠

    造模方法:3% (w/v) DSS自由饮用7天

    image.pngimage.png 

    2Yeasen DSS(Cat#60316ES)小鼠造模实验结果(Xiaona Gao, et al. Journal of Nutritional Biochemistry 83 (2020) 108438. IF=6.048)

    客户3:

    客户来源:中国海洋大学

    小鼠类型:4-5周龄SPF雄性C57BL/6J小鼠

    造模方法:3.5% (w/v) DSS自由饮用一周

     

    image.png 

    3Yeasen DSS(Cat#60316ES)小鼠造模实验结果(Hao H,et al.Frontiers in Immunology.2021.777147. IF=7.561

     

    近三年客户使用翌圣DSS已发表文献(部分)

    2022

    [1] Lujuan Xing, Lijuan Fu, Songmin Cao,et al.The Anti-Inflammatory Effect of Bovine Bone-Gelatin-Derived Peptides in LPS-Induced RAW264.7 Macrophages Cells and Dextran Sulfate Sodium-Induced C57BL/6 Mice[J]. Nutrients 2022, 14, 1479. IF=5.717

    [2] Lei-NingChen,TaoJing,Zi-BinLin,et al.Metabolomic and transcriptomic responses of mouse testis to the dextran sulfate sodium induced colitis[J].Reproductive Toxicology.2022, Pages 35-42.IF=3.143

    [3] YuangengLi,PingYu,WenwenFu,et al.Polysaccharides from Panax ginseng C. A. Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in mice[J].Journal of Functional Foods.2022, 105013. IF=4.451

    [4] Wang S,  Huang J,  Tan KS, et al.Isosteviol Sodium Ameliorates Dextran Sodium Sulfate-Induced Chronic Colitis through the Regulation of Metabolic Profiling, Macrophage Polarization, and NF-B Pathway[J].Oxidative Medicine and Cellular Longevity. 2022,4636618. IF=5.076

    [5] Chenglu Sun, Jingpeng Hao,Hong Qin,et al.Endometrial Regenerative Cell-Derived Conditioned Medium Alleviates Experimental Colitis.Stem Cells Int 2022;2022 IF=3.869

    2021

    [1] Hao H,  Zhang X,  Tong L,  Liu Q,et al.Lactobacillus plantarumEffect of Extracellular Vesicles Derived From  Q7 on Gut Microbiota and Ulcerative Colitis in Mice[J].Frontiers in Immunology.2021.777147 .IF=7.561

    [2] Lingjun Tong, Xinyi Zhang , Haining Hao,et al.Lactobacillus rhamnosus GG Derived Extracellular Vesicles Modulate Gut Microbiota and Attenuate Inflammatory in DSS-Induced Colitis Mice[J].Nutrients.2021, 13, 3319. IF=5.717

    [3] Zhipeng Gu , Yujie Zhu, Fengfeng Mei,et al.Tilapia head glycolipids protect mice against dextran sulfate sodium-induced colitis by ameliorating the gut barrier and suppressing NF-kappa B signaling pathway[J].International Immunopharmacology.96 (2021) 107802. IF=3.943

    [4] JialiDong,YuanLi,HuiwenXiao,et al.Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models[J].Cell reports.2021, 109886.IF=9.423

    [5] Yaohua Fan,Yanqun Fan,Kunfeng Liu,et al.Edible Bird’s Nest Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice by Restoring the Th17/Treg Cell Balance[J].Frontiers in Pharmacology.2021.632602.IF=7.561

    2020

    [1] Jia-Rong Huang, Sheng-Te Wang, Meng-Ning Wei,et al.Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer[J].Frontiers in Pharmacology.2020.586885. IF=7.561

    [2] Gao X, Fan W, Tan L, et al. Soy isoflavones ameliorate experimental colitis by targeting ERα/NLRP3 inflammasome pathways[J]. The Journal of Nutritional Biochemistry, 2020, 83.IF=6.048

    [3] Li, Y., Dong, J., Xiao, H., Zhang, S., Wang, B., Cui, M., & Fan, S. Gut commensal derived-valeric acid protects against radiation injuries. Gut Microbes,.2020 .1–18.IF=10.245

     


    推荐建模专题推荐:DSS溃疡性结肠炎模型的构建